STANDARDIZED EXTRACT FROM ARONIA BERRIES

CARDIOPROTECTION l METABOLIC PROTECTION l LUNG PROTECTION l
ANTI-INFLAMMATORY ACTIVITY l VISION FUNCTION

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High-quality European-origin raw materials

Innovative production line

Extraction without carriers

Innovative drying - vacuum belt drying

High standards and quality

What is ARONVIT?

Aronvit is a unique, standardized extract from selected aronia berries. As a result of our own technology development efforts we have obtained a pioneering, prime quality extract with a rich anthocyanin content.

Aronvit is a dark purple to black fine powder with good technological properties. It can be suitably used in the form of syrup, capsule and tablets.

Anthocyanin fractions::

Cy-3-gal
Cy-3-ara
Cy-3-ksyl
Cy-3-glu
Chlorogenic acid

Anthocyanins and polyphenols

Thanks to a high content of anthocyanins, Aronvit extract shows a wide range of beneficial health results, including a number of positive metabolic changes, as reported in literature.

Extract Aronvit has been standardized for the content of:

anthocyanins (HPLC)
polyphenols (UV)

Aronia is the healthiest berry in the world, with one of the highest scores on the ORAC scale.

In other words, as an antioxidant, it has the highest capacity of absorbing reactive oxygen species (ROS).

Processing and purification of vegetal food affect adversely the level of antioxidant substances. That’s why Aronvit standardized extract with the high content of anthocyanins and polyphenols is a perfect choice to ensure proven, versatile health benefits.

Aronvit is recommended for use by all people exposed to adverse environmental factors, in particular in prevention and assistance to patients with:

• cardiovascular disorder
• diabetes
• hepatic disorders
• in prevention of vision problems
• deteriorating lung function

RESEARCH ON ANTHOCYANINS:

Reactive oxygen species (ROS), i.e. free radicals and molecules which can generate them, are involved in several vital physiological processes. Because the excessive production of free radicals, like their shortage, may be harmful for the body, it is important to keep the balance between pro- and antioxidant mechanisms. Along with the better understanding of the role of oxidative stress caused by ROS in the occurrence of several chronic diseases, anthocyanins has started to be knowingly used as antioxidant compounds with beneficial health effects, and namely with antioxidant, anti-inflammatory, anti-atherosclerotic and antidiabetic action. [1] [2]

IMPACT OF ANTHOCYANINS ON THE CARDIOVASCULAR SYSTEM AND IN DIABETES

Anthocyanins hold good for the improvement of lipid parameter, glucose levels, endothelial function and redox status in the body weight loss. In particular, anthocyanins show protection properties for the cardiovascular system and the heart muscle itself. The positive impact of anthocyanins on the cardiovascular system is associated with their anti-inflammatory properties, their ability to strengthen capillaries, and to slow down the aggregation and adhesion of blood platelets [3]. As it has been observed in animal and human models the vasodilator action, i.e. the relaxation of vascular smooth muscles, helps lower the blood pressure [4][5].
Moreover, a diet rich in anthocyanins improves the plasma lipid profile by reducing the total cholesterol concentration, LDL fraction and triglycerides [6].

The findings from studies conducted on animal models to analyze the protective effect of anthocyanins in insulin resistance and obesity showed that anthocyanins are effective in increasing tissue responsiveness to insulin, in reducing weight gain and lipid accumulation. For instance, in their study of 2017, Yamane et al. [7] demonstrated the suppression of elevation of postprandial blood glucose levels. Finally, anthocyanins help prevent the damage to blood vessels, typical in the course of diabetes, and the positive effect of anthocyanins on microcirculation translates into their positive impact on diabetic retinopathy.

INFLUENCE OF ANTHOCYANINS ON ANTI-INFLAMMATORY ACTIVITY

The anti-inflammatory action of anthocyanins is manifested in the regulation of tension in capillary walls, which in turn reduces the cell inflammatory response. Anthocyanins inhibit, among all, NF-κB and the synthesis of inflammatory mediators (PGE2), and reduce the activity of COX-2. They regulate PLA2, COX-2, LOX enzymes and have the ability to regulate iNOS activity. As a part of their protective function in inflammatory processes,
anthocyanins trigger the synthesis of prostacyclin (PGI2) produced in endothelial cells and foster their anti-aggregation action (like acetylsalicylic acid) [8] [9].

IMPACT ON ANTHOCYANINS ON THE EYE FUNCTION

Anthocyanin colorants improve visual acuity by speeding up the regeneration of rhodopsin or by activating enzymes involved in its production [10].

Anthocyanins reduce the vulnerability to infections (inflammations) and mitigate the existing inflammatory conditions. Based on the animal model it has been demonstrated that their use may be beneficial in non-infectious inflammations such as uveitis [11]. The positive effect of anthocyanins on microcirculation translates
into their favorable action on diabetic retinopathy [12].

NON-ALCOHOLIC FATTY LIVER DISEASE

According to data from 2016, NAFLD is considered as one of the most common causes of liver diseases [13]. Almost half of diabetic patients struggle also with NAFLD, and nearly 80-90% of obese individuals (BMI>30) suffer from the diagnosed NAFLD. As it is commonly known, the accumulation of lipids in liver aggravates oxidative stress, and as a result, inflammatory conditions. Because the production of active oxygen species in the course of NAFLD and insulin resistance are caused by mitochondrial dysfunction, it is suggested to use antioxidants in their therapy [14] [15].

LUNG FUNCTIONS

The study presented at the 2018 ATS (American Thoracic Society) conference confirms that the intakes of
anthocyanins can be associated with a significantly lower deterioration of lung functions in the general population,
and especially in individuals who have never smoked or quit smoking [16] [17].

The positive effects of anthocyanin intake, as describe above, occur as a result of a combined action of several mechanisms. While only some of them are directly connected with the antioxidative effect, and the majority is triggered by anthocyanin indirect action, Aronvit standardized extract with the rich content of anthocyanins is still a reliable everyday source of healthy dietary ingredients.

ARONVIT-BASED PRODUCTS

B-PAC Forte / PAC-on Mind / OxiPAC Forte

yOUR PRODUCT

IN ANY GALENIC FORM

References:

[1] Anthocyanin-rich grape extract blocks breast cell DNA damage. Singletary K.W., Jung K.J., Giusti M.: J. Med. Food, 2007, 10, 244-251. [2] The case for anthocyanin consumption to promote human health: a review.Pojer E, Mattivi F, Johnson D, Stockley CS. Compr Rev Food Sci Food Safety 2013;12:483–508. [3] Anthocyanins and heart health Mazza G.J.:. Ann. Ist. Super. Sanita., 2007; 43: 369–374. [4] Aronia melanocarpa extract reduces blood pressure, serum endothelin, lipid, and oxidative stress marker levels in patients with metabolic syndrome. Broncel M, Kozirog M, Duchnowicz P, Koter-Michalak M, Sikora J, Chojnowska-Jezierska J. Med Sci Monit. 2010 Jan; 16(1):CR28-34. [5] Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts Bell, D.R.; Gochenaur, K.. J. Appl. Physiol. 2006, 100, 1164–1170. [CrossRef] [PubMed]. [6] Legal requirements for „functional foods” claims. Noonan W.P., Noonan C.: Toxicol. Lett., 2004; 150: 19–24. [7] Aronia juice suppresses the elevation of postprandial blood glucose levels in adult healthy Japanese Takuya Yamane, Miyuki Kozuka, Mio Wada-Yoneta, Tatsuji Sakamoto, Takenori Nakagaki, Yoshihisa Nakano, Iwao Ohkubo Clinical Nutrition Experimental 12 (2017) 20e26. [8] Anti-inflammatory activity of polyphenolic compounds Postępy Fitoterapii 1/2017, s. 17-23 K. Owczarek, J. Fichna, U. Lewandowska. [9] Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula] Bagchi D., Sen C.K., Bagchi M., Atalay M.:. Biochemistry, 2004; 69: 75–80. [10] Anthocyanins and anthocyanin-rich extracts: role in diabetes and eye function Ghosh D., Konishi T.:. Asia Pac. J Clin. Nutr., 2007; 16: 200–208 Therapeutic Eects of Anthocyanins for Vision and Eye Health. [11] Anti-inflammatory Effects of Aronia Extract on Rat Endotoxin-Induced Uveitis K. Ohgami, I. Ilieva, K. Shiratori, Y. Koyama, Xue-Hai Jin, K.Yoshida, S. Kase, N. Kitaichi, Y. Suzuki, T. Tanaka, S. Ohno. [12] Review Article Anthocyanins and anthocyanin-rich extracts: role in diabetes and eye function D. Ghosh, T. Konishi Asia Pac J Clin Nutr 2007;16 (2):200-208 200. [13] NRF-2 and nonalcoholic fatty liver disease, A. Solano-Urrusquieta, J. A. Morales-Gonzales, G. E. Castro-Narro, E. Cerda-Reyes, P. D. Flores-Rangel, R. Fierros-Oceguera, Annals of Hepatology 2020. [14] Non-alcoholic fatty liver disease: beneficial effects of flavonoids Akhlaghi M.. Phytother Res. 2016;30(10): 1559–1571, doi: 10.1002/ptr.5667, Pubmed: 27307131. [15] Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, et al. (January 2018).. Nature Reviews. Gastroenterology & Hepatology. 15 (1): 11–20. [16] Dietary Intake of Anthocyanin Flavonoids and Ten Year Lung Function Decline in Adults from the European Community Respiratory Health Survey (ECRHS) V. Garcia Larsen, R. Villegas, E. R. Omenaas, C. Svanes, J. Garcia-Aymerich, P. G. Burney, D. Jarvis. [17] Dietary anthocyanin intake and age-related decline in lung function: longitudinal findings from the VA Normative Aging Study A. J Mehta, A.Cassidy, A.A.Litonjua, D.Sparrow, P. Vokonas, J. Schwartz.